RF - Generalized Morphea: Definition and Associations

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Generalized morphea: a case report.

Generalized morphea is a subtype of localized scleroderma that lacks systemic manifestations. It is a rare condition in which idiopathic sclerosis of the skin occurs in a widespread manner. We report a 37-year old Thai female who presented with multiple hypopigmented lesions on right leg and right arm with a skin biopsy showing the typical sclerotic change. The patient responded to treatment wi...

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Fasciitis associated with generalized morphea.

Figure 1. Photograph of the legs. A large, thickened, firm, hyper/hypopigmented plaque is evident on the left leg. Figure 2. Biopsies of affected skin (A) and contiguous tibialis anterior muscle and fascia from the left leg (B–D). (A) The der-mal collagen is thickened, packed, and hyalinized. The subcutaneous fat is extensively replaced by collagen, and perivascular inflammatory infiltrates are...

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Generalized Morphea: a Case Report

Generalized morphea is a subtype of localized scleroderma, which lacks systemic manifestations and displays widespread, multiple, well-circumscribed, indurated plaques. We represent a 46-year-old woman with generalized morphea. More than 3 years ago she developed multiple, nonpruritic plaques symmetrically on the trunk and extremities. The patient’s clinical history, laboratory analysis and his...

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Unilateral generalized morphea: A case report

Morphea is a localized form of scleroderma characterized by sclerotic plaques limited to the skin. Although its cause is unknown, genetic, infectious and autoimmune mechanisms have been suggessed in the pathogenesis of the morphea. It is more common among childen and young women. Although the prognosis is generally good, it sometimes causes significant morbidity. Morphea has five subtypes as pl...

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Unilateral generalized morphea: A case report and literature review

Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea is termed unilateral generalized morphea (UGM). UGM is characterized by indurated plaques ...

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ژورنال

عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)

سال: 2021

ISSN: 1578-2190

DOI: 10.1016/j.adengl.2019.05.023